RHB-101

RHB-101 is a once daily controlled release proprietary formulation of Carvedilol. Carvedilol is marketed under various trade names including GSK’s Coreg®. The product was licensed from Egalet a/s (a private Danish company) in November 2009. As Carvedilol, RHB-101 is a β-adrenergic blocking agent with α1-blocking activity and is planned to be indicated for the treatment of heart failure, left ventricular dysfunction (following myocardial infarction) and hypertension. Several clinical PK studies were conducted and RedHill is currently executing its development plan.