RHB-104 is a proprietary antibiotics drug combination for Mycobacterium avium paratuberculosis (MAP) infection in Crohn’s disease.* RHB-104 was acquired from Sydney-based Giaconda [ASX: GIA] in August 2010. RHB-104 will be indicated for treatment of MAP infection in Crohn’s patients, suspected as the underlying cause for Crohn’s disease symptoms. There is currently no available treatment for MAP infection in Crohn’s disease, and no other effective cure for Crohn’s disease. Current standard of care includes 5-ASA agents, corticosteroids, immunomodulating drugs (e.g. Methotrexate) and anti-TNFα (e.g. Remicade, Centocor (J&J)). However, standard care leaves an unmet medical need for a long lasting treatment with low side-effects. RHB-104 holds promise for providing long term remission with reduced side-effects allowing affected patients to lead normal lives. RHB-104 demonstrated promising results in phase II and phase IIIa trials in Australia and has an IND status in the US. RedHill is currently executing its development plan.
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*Selected references:
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